In general, no. Fudging can be a useful way to put a finger on the scale when random chance has dealt unusually unlikely and undesirable outcomes, but the less "swingy" your game's math is, the less you need to do it. I don't find 4e to be very swingy, so I don't do it anymore.
...actually, there's one circumstance where I would fudge a die roll these days. If the party is winning a fight, and a monster has one really cool thing he hasn't done yet, and I think that letting the monster do his cool thing will be more interesting than having him die without accomplishing it, then I might fudge to let the monster hit with his cool trick.
...actually, there's one circumstance where I would fudge a die roll these days. If the party is winning a fight, and a monster has one really cool thing he hasn't done yet, and I think that letting the monster do his cool thing will be more interesting than having him die without accomplishing it, then I might fudge to let the monster hit with his cool trick.