My friend ran a campaign where we were all lizardmen (the society was not politically correct), recruited by the advisor of our glorious king to ensure that the kingdom's team for the annual Aztec-esque sporting championship would be in peak physical condition, and that meant sacrificing humans in a distant volcano in order to gain the fire spirit's favor, so that the team's hot tub would be the perfect temperature.
Cue four cold-blooded lizardmen dragging two wagons full of whimpering mammalfolk through perilous wilderness, trying to keep the morons from getting eaten by giant spiders or drowning when we tried to ford a river. We ended up bailing on the whole mission when we met some rude mind flayers who we discovered were using psychic relay stations to illegally scry on our sporting events (aka, they were pirating ESPN), and we just turned our wagons full of human sacrifices into food trucks for the illithids, who paid in magic items.
Unfortunately, we discovered later that the championship was being played against the gods of the underworld, and our team lost, which led to the annihilation of our entire culture.