Puzzles:
Pick some IRL not-popular TV program, and use character names, locations, &c. The way to get through a locked door is to provide the right trivia answer to the computer console / lock.
To get through the sound-detecting alarm, turn on a circulation fan and point it at the protected room; the computer will screen out the white noise. Then step very quietly through the room and out the other side.
"Use your Arcana skill" to figure out the chemical coding and figure out which two tubes to break open and spill together ... and/or which two to NOT mix. (Have you ever read a Material Safety Data Sheet? Plenty of legalese jargon in there.)
Somebody else came through a long time ago but never finished his exploration. (Maybe you find his body later.) You do find the pit trap and other primitive tricks he left behind to protect what he thought was valuable.
Indiana Jones style traps, covered with even more dust than in 1930s.