I still think D&D "needs"--or could benefit from--a new default, kitchen sink setting to place their adventures in. I like the Realms, but at this point it feels worn out. Anachronistic, even. A new--built from the ground--kitchen sink setting could allow them to bring D&D fully into the 21st century without feeling like everything new is being crammed into old settings (e.g. dragonborn in Greyhawk...blech). I feel that WotC could take a lesson from Paizo, and create a Golarion-esque setting that allows for a more naturalistic diversity of ideas...not just pasting on everything, whether it fits thematically or not (e.g. Kara-Tur/Zakhara/Maztica in Toril).