From a monetization standpoint, no and yes.
No: The last book I bought was Tasha's, and I'm not likely to buy any of the new books based on the design direction and quality failures I perceive. I have bought none of the adventure books, as according to the reviews they usually tend to be railroady and disjointed. I homebrew my own campaigns, and enjoy creating monsters. The only thing I'm likely to buy is a module book to run things with less prep, and the only one that sounds sufficiently fun is Ghosts of Saltmarsh. As others have said, the DM's Guild has lots of options for modules.
I have two monster manuals, and that's about enough. Also, the WOTC monster manual is poorly organized; enemies should be grouped by category instead of by alphabet. If they're fighting a pack of 3 different types of spiders, why do I have to look up Spider, Insect Swarm, Phase Spider, and Giant Wolf Spider on four different pages in the book?
I own the big 3 for player options on DND Beyond, and am hoping that the 2024 release doesn't mess up the owned content by overwriting it with stuff I won't/can't use.
Yes: I've sold a bit over $1k in stuff on the DM's Guild, with Castle Dracula (Castlevania) being over 125 copies. I've made more money on 5e than I've spent on it, as long as you count my time as free! WOTC's cut is 20%, so they've made over $200 in profit on me. If their profit margin on a book that goes to the distributor at $20-$25 is 40% ($8-$10), then they've done the equivalent of selling me 25 hardbacks. That's pretty good!
Also, I watched the D&D movie in a theater, and then again on streaming rental with my wife.
For me, 5e is a great edition compared to 3.5 and 2e (no experience with 4e) and easy to work with / write for despite some flaws. I'm sure there are other great systems, but there's a powerful network effect with players. ACKS2 is appealing, but I look at it and go "Who would I run it for? Who would run it for me?" Additionally, I don't really want to have to learn a new system and lose easy use of what I've inadvertently memorized, and teach my players new rules, plus I like the use of the deep lore (time traveling illithids from the future to the past, etc.) that sits in the background for those of us who care.