I actually like a lot of the post-Spellplague realms. I'm not excited for all of it (I care nothing about Returned Abeir _OR_ Maztica, for example), and some of it's just kinda dubious, but it seemed a lot more fertile for adventure.
Basically, it's a lot easier for the story to be about the PCs when it's not instead about a ton of NPCs, or areas that are so thoroughly detailed that canon becomes an itchy trigger word.
Course, I'd be fine with some other setting too.