I'm mostly intrigued by the combination of the two design philosophies. I'm ambivalent about mecha, and I don't have much experience with 4e beyond a couple aborted tier 1 campaign attempts.If you enjoy D&D 4e tactical combat puzzles, mecha, or middling high-concept modern space opera settings there's probably something you'll like in Lancer. If you like more than one of those things, it's almost guaranteed even if you only use the game for inspiration and idea mining. Unlike 4e it comes with a complete and fairly compelling setting.
The art is gorgeous too, if that's a selling point.