I wouldn't call it a successful product launch. Just because WotC's warehouse ran out of books doesn't mean distributors and stores ran out of books.
Simply put distributors over ordered and the books aren't moving. Yeah WotC had to go to a second print run.. but if it was needed... why cancel projects and fire employees. Because they're losing money.
Uhm...no.
First, having heard from quite a lot of people at all stages of the distribution chain, 4e is selling. Well. And so are adventures, which means people aren't just buying, but actually playing. Whether or not you like 4e, its commercial success is an objective fact. (I have never understood why people seem compelled to conflate "I don't like it" with "It's a commercial failure". Most of my favorite TV shows were canceled early, and Robert Jordan is (well, was) a best selling writer. A sure sign of pure Nerd Rage overwhelming the logic circuits is when someone claims something is a 'failure' on no basis other than 'I don't like it' -- see unending "WoW is dying!" posts on MMO forums for good examples.)
Second, assuming the layoffs are correlated directly to 4e sales is specious at best. Consider:
a)Development is over. Maintenance is a lot easier. Fewer people are needed.
b)4e "raised the bar" as to what level of sales could be expected. Product lines which seemed to be "acceptable" now look "underperforming". Why not cut them and shift the survivors to D&D?
c)It's always easier to bring in the next crop of freelancers at reduced salaries and get rid of the old hands who have earned benefits.
d)If 4e was a flop, wouldn't the Brand Manager be getting the axe as well?
e)Corporations don't use Earth Logic. Attempting to apply it will always result in headaches and wrong conclusions.
f)Gleemax was the "shot across the bow". Someone at corporate realized,too late, that they couldn't outdo MySpace. This has nothing to do with 4e's success.
IAE, if you want to argue "Is 4e a success?", take it to a forked thread.