It depends on my group. I like using adult themes, as they can provide a rich source of drama. If your group consists of mature adults, I highly recommend giving it a shot at least once. Likely someone will be made uncomfortable, but you really never know until you try.
Best example of an Adult Situation was in a game (non-D&D) where I had a female PC assaulted, and planned to be raped. She was (barely) able to fight off her attackers and avoid the rape, but due to the way it played out, everyone would think she was raped if the situation was revealed. In the setting we were using, this would be a serious issue for her. She had to decide if she wanted to reveal the event and be publicly shamed (probably resulting in her suicide and that of her fiance who failed to protect her), or let the offenders get away with it. After a great session, she decided to let the matter drop... until she had enough gold to hire an assassin!
Oh, and in case you were curious, the player was also female, and everyone had a great time in that session. The player complimented me on it afterwards, thanking me for not shying away from such a taboo subject.