Merry Christmas, Milk Drinkers! (Skyrim)

A dusty, old tome landed under my tree this year: the Official Game Guide to Skyrim. This is, maybe, 600 pages of maps, quests, gear, monsters, cities, NPCs, and probably a lot more. Which can mean only one thing: it's time to run a Skyrim campaign.

I'll be running it with another gift to grace my tree this year (Modos RPG 1.4), so my question to you:

Have you run a campaign from a book that wasn't tied to an RPG?
What went well, and what could have been done better?

This question extends to Dragon Kings as well, which is an awesome project about which I haven't heard peep lately.

http://www.dragonkingsproject.com/worldbook/

It’s not quite the same thing, but I’ve run campaigns for both the old Star Wars RPG and the Macross/Robotech RPG. My biggest difficulty was trying to constantly get the tone of the source material right. I think if I had to do them again, I’d concentrate more on telling our own tales within the framework provided.

On the other hand, having a shared frame of reference can really work to your advantage. We all know what an AT-AT looks like, and we all know not to mess with Darth Vader. Or, say, that Ulfric Stormcloak is a jagoff.

I ran an Everquest campaign from one of the popular wiki's before Sword and Sorcery published it for d20.