In a "sandbox" game, having all significant encounters tailored to the party's level isn't necessary or likely. A good sandbox has a range of difficulty in its encounters, and the party will gravitate to the encounters of the appropriate difficulty - avoiding the ones that are too difficult.
Of course, "significant" in a sandbox is entirely in the eyes of the party and the story that they and the DM are creating between them.
However, once you get to your planned (story) adventure, you get encounters that the party must overcome if they're to continue the adventure. Most published adventures have this type of encounter. The Giants series do; Keep on the Borderlands doesn't.
At this point, you need a much better grasp of relative balance between party and monsters - and you can get wide variance between groups' experiences with adventures as a result!
Cheers!
Of course, "significant" in a sandbox is entirely in the eyes of the party and the story that they and the DM are creating between them.
However, once you get to your planned (story) adventure, you get encounters that the party must overcome if they're to continue the adventure. Most published adventures have this type of encounter. The Giants series do; Keep on the Borderlands doesn't.
At this point, you need a much better grasp of relative balance between party and monsters - and you can get wide variance between groups' experiences with adventures as a result!
Cheers!