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Message: <blockquote data-quote="arscott" data-source="post: 5250411" data-attributes="member: 17969">Do your players want to play the sort of alchemists who solve problems with their keen intellect and understanding of elemental theory?  or the sort of alchemist who solves problems with explosions?  Because those dictate very different sorts of campaigns.For the thinky side of things, I'd recommend Harry Potter as an inspiration--mostly mystery and political type stories, with actual combat popping up only on occasion.  Ars Magica might be a good starting point, system wise.For the blow-em-up style, d20 or similar should work great.  Aquisition of power as the goal for both the party and the villians--battling over hard to find reagents and lost alchemic formulae.</blockquote>