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Message: <blockquote data-quote="(Psi)SeveredHead" data-source="post: 5667797" data-attributes="member: 1165">I think even giant protozoans could be called shot, to the nucleus or contractile vacuole, for instance <img src="https://cdn.jsdelivr.net/joypixels/assets/8.0/png/unicode/64/1f642.png" class="smilie smilie--emoji" loading="lazy" width="64" height="64" alt=":)" title="Smile    :)"  data-smilie="1"data-shortname=":)" />I say no. My first experience with called shot rules in 2e was in a high-power 2e campaign. I was a 13th-level ranger and the weakest character in the group. Our DM wasn't very experienced; he would use monsters like a horde of ogres. I would called shot twice each round, blinding an ogre, but the DM gave them no penalties for having no functioning eyes. Why introduce a house rule if you won't use it? Apparently he thought it was too easy (it was!). He also considered called shots to the head a violation of the paladin code, which I thought was more than a little odd.I think Pathfinder has a neat way around. Some of the fighter feats blind/nauseate/whatever enemies on a critical hit. You can't really plan around that.I like an idea I saw further up this thread where effects like blindness don't last that long, so it'd only be a temporary advantage to the attacker. There are a few 4e powers that do exactly this, like the rogue's blinding barrage.</blockquote>