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Message: <blockquote data-quote="ExploderWizard" data-source="post: 5892987" data-attributes="member: 66434">You have a setting and a major focus already. The things to detail will be the general starting area, the major power players in that area, and events and schemes taking place in the region. To start: 1) Define the starting region: Your setting might do a lot of the heavy lifting for you on this. Get a general idea of where the major NPCs are based , adventure sites or dungeons are located, etc. Make custom copies of maps that you draw things specific to your campaign on. Decide generally who or what lives where.  2) Detail Major Players: Decide who is in charge and of what. Just sketch the most powerful bad guys and good guys, their relationships and general resources and power level compared to each other.  3) Events and schemes: Come up with a recent history that briefly details how the current state of affairs has come to be then sketch out a rough timeline of how things will come to pass without PC involvement. Give each of your power players some goals and plans to acheive them. You can also sprinkle in  some random events like catastrophic storms, eruptions, dragon attacks, etc. that are independent of NPC plans.  This will give you a good foundation to start creating scenarios to get the PCs involved in the area.</blockquote>