...but you didn't actually say how you would rule it. That is: horizontal (0 degrees) means the cloud moves. vertical (90 degrees) means the cloud does not move. Would it climb up a 45 degree slope? 80? 10?
Perhaps it stops at a 90-degree "slope," and simply moves more slowly up an 80-degree one. Therefore it moves more quickly down a (-80 degree) slope. OK, I'm treading into houserule territory, but...one of my players has memorized Cloudkill and I can tell he's itching to use it.
The party is deep in one of the WotC adventure-series modules, at a part where the entire structure is canted 30 degrees off from horizontal (seek the pun here). There are no vertical walls; there are no horizontal floors. Even if he launches said cloud along the most horizontal line (say, where left is 30 degrees down and right is 30 degrees up), the cloud still moves straight, and does not veer left, yeah? and if he launches it to his right (30 degrees up), it moves along and stops at the wall (since the wall is 120 degrees from the horizontal, treading into ceiling territory). and if he launches it to his left (30 degrees down), it moves down, and upon reaching the far wall (which is 60 degrees from horizontal), does it climb?