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Message: <blockquote data-quote="Set" data-source="post: 3186111" data-attributes="member: 41584">This is particularly suitable for a disease or toxin that is extraplanar in nature, or crafted from the essence of an extraplanar life-form that is spell-resistant.  To make it hard for the PCs to get ahold of and use after the fact, have it be unable to survive outside of a host body in the material plane.  The poison or contagion couldn't then be harvested to be used by the PCs, it has to be inflicted by the extraplanar creature it comes from, and cannot survive outside of a living host.  Only the bad-guy knows the spell, having researched it himself, to summon the Far Realms beastie that inflicts said toxin / contagion, and only he knows the cure (which is to summon the same beastie, which has the power to re-absorb it's host-larvae / parasitic-spores / toxic-blood into itself, 'curing' those infected).Specifically designed curses, perhaps from items, or spells to possess a person with a minor spirit that is capable of inflicting sickness when you go against it's wishes (or the wishes of the person who implanted it) also work (similar to the Symbiont idea, but using possessing spirits or fiends, instead of organisms).Radiation, perhaps from some dull gray stone found only at a juncture between the planes of earth, fire and positive matter, could make for a debilitating effect that can't be removed as a Curse, Disease or Poison, only via a Heal spell or greater effect, and even then, only after the radioactive material is removed from the body of those afflicted (after being put there via grinding up and putting in food, or something).</blockquote>

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