First up, the campaign models in D20Future are pretty short. They consist of a few paras of background stuff, and a AdC or monster.
But it's basically cthulu influenced, rather than other stuff. The idea is that there's a force from beyond the stars called The Void, which infects people (humans or whatever) and takes over their mind, in an effort to rule the universe. In opposition is a group called the Church of the Stars, who fight them. There's a template for the void touched, and a AdC for the purifiers of the Church of the Stars.
And that's about it. The idea is that most people can't tell the void is there, but the heroes , for whatever reason, can.
It's kinda cool, but like all of the campaign models (and in fact the book itself), it needs a fair wack of work before it's actually playable.
I'm intending for my campaign to be loosely based on this model, but the players won't be aware of it from the get go. Rather a purifier will tell them later. I imagine that the Void is something that infects people when they travel through jump gates - the spaces between the stars. There are some cool menace manual monsters (not to mention CoC ones) that might get dropped in later on, peraps as the Void begins to try to take over...