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<blockquote data-quote="Umbran" data-source="post: 5710102" data-attributes="member: 177">You're in a fantasy world, an world without science - mundane explanations like modern germ theory don't need to apply.&nbsp; Since you don't have any scientists pointing out the metabolic pathways and cell division mechanics of microbes, or explicating the operation of the human immune system, you can do anything you like.&nbsp; You're perfectly in your rights to say, &quot;This bug is so pernicious that, even though it isn't magical itself, it requires a high caster level to kill it off.&quot;&nbsp; But you can even leave off the &quot;bug&quot; part - that's still modern science talking.&nbsp; Maybe it is an odd imbalance of humors that the spell cannot correct, or a result of some ancient program of breeding slaves in a long-dead empire such that all their descendants (now basically everyone) are subject to a vulnerability only now discovered after an ancient cask from a mummy's tomb is opened....Beyond &quot;valid to rule&quot;, the spell description says so explicitly (from the d20 SRD):&quot;Note: Since the spell’s duration is instantaneous, it does not prevent reinfection after a new exposure to the same disease at a later date. &quot;</blockquote>

[QUOTE="Umbran, post: 5710102, member: 177"] You're in a fantasy world, an world without science - mundane explanations like modern germ theory don't need to apply. Since you don't have any scientists pointing out the metabolic pathways and cell division mechanics of microbes, or explicating the operation of the human immune system, you can do anything you like. You're perfectly in your rights to say, "This bug is so pernicious that, even though it isn't magical itself, it requires a high caster level to kill it off." But you can even leave off the "bug" part - that's still modern science talking. Maybe it is an odd imbalance of humors that the spell cannot correct, or a result of some ancient program of breeding slaves in a long-dead empire such that all their descendants (now basically everyone) are subject to a vulnerability only now discovered after an ancient cask from a mummy's tomb is opened.... Beyond "valid to rule", the spell description says so explicitly (from the d20 SRD): [I]"Note: Since the spell’s duration is instantaneous, it does not prevent reinfection after a new exposure to the same disease at a later date. "[/I] [/QUOTE]

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