@NotAYakk How would you simulate the "baseball bat hitting a tank (MD) would never do any damage" effect from Rifts?
I mean, 10x damage is enough? Just ... round down.
Suppose you have a 25 strength level 20 fighter using a +3 club and duelist style. They do 1d4+12 damage; they'll do a single point of KHP. The same fighter with 29 strength, GWF, using a flametongue greatsword does 4d6B+19, or 2-4 KHP; a scratch.
But those are legendary scale mortals. Having them able to scratch Kaiju-scale foes isn't implausible.
A less heroic human with 12 strength will do 1d4+1; 0 KHP. Low-heroic monsters (like a Knight) deal ~1 KHP per attack. Making a non-heroic character capable of dealing even a single KHP of damage will be tough. In 5e parlance, every non-Kaiju acts like a "CR 0" foe.
The 100x factor I think isn't fully needed. It means that a single point of Kaiju-scale damage is instant death; in RIFTS this translates to every human-scale figure miraculously having MDC armor or whatever, and makes "I'm a human running around a Kaiju-scale battle" less interesting. With only 10x a mid-high level PC might actually survive a minor damage effect.
Like, a level 11 foe might do 5 damage to everyone within 1 square when they teleport; a minor amount of KHP, but scaled to human size that is a 50 point insane damage blast. At 500 (100x) it just means "you die"; at 50 (10x) it means "holy crap you are almost dead".
If you did use 4e style monsters for Kaiju-scale battles, a level 11 Kaiju has (3+11)
* 8 = 112 KHP, roughly 1120 normal HP. They are doing about 13 KHP per attack, or 130 normal damage. If we remove +1/2 level scaling from 4e AC/ATK/etc, they have about 18 AC and +8 to hit. A balanced encounter is 4 of those (!); a solo L 11 foe does ~260 damage and has ~4480 normal HP.
The scale is pretty much there. And a tweak on AC/saves from lower-scale foes would make them near immune.
Sure, world simulation it might not be perfect. But I think it would make a good gameplay simulation; nobody would want to fight Kaiju-scale foes without their Kaiju-scale gear.