I'm playing three games right now.
1. Wednesday nights, D&D. We're playing normal gamers from our reality who were killed by the plot of an Aztec god, and ended up in the Aztec underworld. We have to fight our way through to get back to our normal selves. We hope to figure out how to stop the Aztec god by the time we get back there. So far, we have a vaccine for the engineered disease he killed us all with. It's interesting. My character is a rather screwed up guy, one of the burned-out people you see hanging around cons in a fatigues jacket who always looks hung over or stoned. He was a drug dealer in the normal world, and is now a scout who's working toward becoming a werejaguar cultist of the god of darkness.
2. Sunday afternoon, Buffy the Vampire Slayer. I'm playing the group's Watcher, a former Green Knight (a British eco-terrorist group). He joined the Watchers when a chaos demon used his terrorist cell to kill a whole bunch of people. The game's plot apparently centers around some kind of apocalypse, or at least so far it does. It's Buffy, after all.
3. Sunday evenings, d20. This is a historical horror/fantasy game, set in 1760s Boston. The rules are based on d20, with a new set of base classes and some other rules specific to the setting. Think Call of Cthulhu and Dark Matter. The PCs are agents of a British organization devoted to protecting people from the supernatural. I usually run it, though other group members do occasionally run an adventure. When that happens, I play a Catholic demon-hunting paladin.
