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Message: <blockquote data-quote="I'm A Banana" data-source="post: 6847052" data-attributes="member: 2067">I think how you handle it might depend on what you want to get out of it.Do you want to take the "classic werewolf" angle and have them wrestling with a curse that causes them to murder people? A curse that they want to get rid of, or maybe suspect they are better off dead then left alive with? Do you want this to be a "how Spiderman got his powers" angle and have them embracing the curse and using it to kick butt?Something else?If you first figure out if you want this to be a problem for them or not, you can let your design flow from that goal. If it's meant to be a problem for them, you have them kill people and have their minds lost and generally have that failed CON save result in horrible things for the story and their mission.If you don't want it to be a problem, maybe give them game elements (feats, PrC levels, whatever) that they can take to enhance their power and control, and maybe worry a bit more about what embracing the curse means in terms of your world. Either way, sounds like a good time. <img src="https://cdn.jsdelivr.net/joypixels/assets/8.0/png/unicode/64/1f642.png" class="smilie smilie--emoji" loading="lazy" width="64" height="64" alt=":)" title="Smile    :)"  data-smilie="1"data-shortname=":)" /></blockquote>