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Message: <blockquote data-quote="James Gasik" data-source="post: 8590355" data-attributes="member: 6877472">The Ready rules say you can respond to a particular, perceivable circumstance.  But that the action goes off after the trigger.  If the trigger is "the enemy becomes invisible", it comes down to the DM's interpretation of whether you vanish all at once or fade from view gradually.I think most tables would run it as an instant "Ninja vanish!" and thus you can't react to the trigger, because after the trigger has resolved, magic missile no longer has a legal target.If, however, you readied against casting a spell, that certainly works because you have to complete the components of the spellcasting- even if they don't require a lot of fanfare, it takes at least some time to shake your arcane focus and shout "Evanesco" (or whatever the kids are saying these days).</blockquote>