Actually, Hoog just started a campaign where Elves, Dwarves, and Gnomes rule the world with iron fists (no velvet gloves) and our PC's are members of the "slave" races... Humans, Halflings, Half Elves, Half Orcs, and any monstrous humanoids from the MM that have a +0 level adjustment. Since I've not had the opportunity to play monster races I thought I'd give it a shot with an Orc Ranger/Barbarian, with a favored enemey of Elves. The Orc Paragon class fits seamlessly with the character, and since we're starting at 3rd level He's got one level of paragon already.
I'd probably be more hesitant to try a spellcasting paragon though, giving up even one level of spellcastng is a high price to pay.
Chris