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Message: <blockquote data-quote="Legildur" data-source="post: 3230708" data-attributes="member: 1258">Let's look at the relevant rules.  From the SRD, Sanctuary says the following:So the spell affects attacks.  Grapple is listed under the "Special Attacks" heading and the opposed "grapple check is like a melee attack roll".  Note that it doesn't actually come out and call it an attack (although there is a melee touch attack to start the grab, or, as in this case, there is the Imrpoved Grab ability, which starts off from a successful attack).The PHB glossary says that an attack is "Any of numerous actions intended to harm, disable, or neutralize an opponent."  The opposed grapple check certainly fits that criteria.Therefore I would say that the Sanctuary spell would have prevented the owlbear from attacking, or grappling, the barbarian.  However, the barbarian would not be able to use a grapple check to escape the grapple on his turn, as this would be an attack and break the spell.  Of course, use of the Escape Artist skill would be just fine, as would waiting for the owlbear to let go and move onto another target.</blockquote>