I would ask how easilly accessible is it?
For example if the local church has a rod of resurrection, how is that different than a sarcophagus? They still have control of it.
Is it attached to a specific Diety? Or a magical device not attached to any diety?
Now if its an item found in a campaign I would say ouch, unless like a staff it has charges. Or maybe rathter than charges it takes a fuel (gold or similar valuable) to work the magics. Basically a sacrifice to the god that powers it.
I would think about adding some hinderences to it, similar to the show, where if you used it when fully healed or too much, you would get addicated, but thats going down another avenue.