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Message: <blockquote data-quote="3catcircus" data-source="post: 5484285" data-attributes="member: 16077">How "realistic" do you wanna go?  How much combat will occur?  If you are looking at a gritty world where the PCs do a lot of fighting with human enemies within the bounds of the real world (e.g. cultists, mad scientists, Evil with a capital E serial killers, etc.) then you might try the (out of print but available on RPGNow) Twilight:2013 rules (and just ignore the military-heavy portions of the equipment lists and backstory).  While the mechanics are definitely front-and-center, the character generation and advancement is top-notch - what I've found is that it forces the players to focus on really putting some thought into their PCs backgrounds - something that is invaluable when putting together a bunch of plot hooks that invest the players into the campaign.On the other hand - if you are going for a less realistic game, I think either WoD or Supernatural would be fine - they are both fairly abstract rules sets.  The only issue is that WoD has a heck of a lot more support material than Supernatural.  Of course, if you don't mind kit-bashing, the Cortex rules at the heart of Supernatural gives you much more control than WoD.</blockquote>