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Message: <blockquote data-quote="weem" data-source="post: 4881200" data-attributes="member: 9470">First of all, a disclaimer... I'm not a math guy. I'm also not good at catching problems that can break systems/balance/etc.With that said, I love thinking up these kinds of things - but I'm work and don't have much time so I am going to brainstorm here...So the first thing I think is, because you are wanting these diseases to have bad AND good effects, we need to think of the good (I think the bad side is a bit easier - these are diseases after all).So the first place I would start is stat bonuses/penalties because it seems obvious (and you have initial states starting with them). If these are intended to be something that's not entirely bad, you will have to think of the benefit from a PC point of view - so in other words, what stat adjustments will they be okay with. For example, certain strikers might not mind something that gives him DEX at the cost of CON, or a controller gaining INT but losing WIS. Maybe you come up with quick lists of these (+1 DEX. -2 CON... +1 INT, -2 WIS... +1 STR, -2 DEX) and think of a theme for them.First things that comes to mind...Rage Fever:Symptoms include weight loss, paling skin, lack of patience. As the body thins, it  gains a heightened sense of responsiveness while becoming simultaneously more prone to various ailments. Victims are described as Gaunt, Frail and quick to temper.----Initial State+1 DEX-2 CONMind Sapper:Symptoms include an inability to focus on more than one thing at a time, but this focus on one thing is very defined and intense. Victims feel as though they are in a constant state of drowsiness, except when they find a topic they focus on - it allows them to zone out everything else and concentrate on one thing. At the same time however it makes them oblivious to what is happening around them. They become less aware of how their actions are effecting others. Victims have been described as Distant, Uncaring, and Forgetful. ----Initial State+1 INT-2 WISAgain, these are off the top of my head real quick and you don't have to use them - I was attempting to show you how you might come to design some <img src="https://cdn.jsdelivr.net/joypixels/assets/8.0/png/unicode/64/1f609.png" class="smilie smilie--emoji" loading="lazy" width="64" height="64" alt=";)" title="Wink    ;)"  data-smilie="2"data-shortname=";)" />*goes back to work... kind of*</blockquote>

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