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Message: <blockquote data-quote="Maxperson" data-source="post: 8434848" data-attributes="member: 23751">Yes.  That's what the PHB tells you, and the DMG confirms with respect to which deities are available and what domains they have.Ask Crawford.  He made the PHB rules that tell you to ask the DM which things are available for making characters, and the DMG rules giving the DM all of the authority over which gods are present and with which domains.Up to your DM.  If you came to me with a nature cleric of Vecna, though, I'd tell you to pick a nature god or go with knowledge/trickery.We know that the number of non-human worshippers of HUMAN gods is very small.  The vast majority worship their own gods.  That is written in various editions.It intends them to be human gods, yes.Since by RAW portfolio=domain, without being a god of nature, Vecna cannot have the nature domain.</blockquote>