Hiya!
Sure, why not? I have no problem with it. Those saying "it's made up of very small objects"...yeah, and so is a rock; it's just that in the rock they are more densely packed.
The only thing I'd have to adjudicate is the "amount", as weight isn't going to cut it. I'd probably go with "a 10x10x10 cube of gas that the caster can see". This would give a decent amount of material, and it would cut down on rules lawyers trying to pull the "I move the sarin gas ( O-Isopropyl methylphosphonofluoridate ) down the hallway to kill all those in it, 10' at a time!" shenanigans.
Wizards in 5e already have significantly reduced number of spells...so I see no need to try and limit them any more than needed.
^_^
Paul L. Ming