Well, as the 'Too Big To Deal With' villains, there are the Calaseans. The Calaseans are powerful natural magic users who, for all intents and purposes, control the world. Every other race is either enslaved by them, allied with them, or at war with them. They're not over the top, they merely ARE. Calaseans are extremely evil in that they don't see any other race, especially their slave races, as worthy of any sort of consideration at all. The bottom line with the Calaseans is that what we call Moral is of no concern to them - it isn't a part of their thought processes.
Humans are the number one slave race of the Calaseans, living in great plantation areas on four different continents.
The action takes place in The Wild Lands, which is essentially a neutral zone between the Calasean plantation area on this continent, and the homelands of the Elorhim, the only race capable of standing up to and defeating the Calaseans on their own terms.
In this neutral zone are approximately 200,000 (for current setting) Humans trying to establish the first "free" Human nations.
In the north of the Wild Lands are the Morgothians - worshipers of Morgoth, the LE God of Strength and Fire. The Morgothians are kind of like the old Soviet Union on steriods, except without any pretenses of serving the common man. Everybody spies on everyone else and every priest of Morgoth is a part of a great monolithic organization bent on turning the entire region into a vast darwinian state ruled by themselves. In their minds, this is the only way of creating the strength to deal with the Calaseans and/or survive any attempt by the Calaseans to wipe out free Humanity.
Then, of course, there are several organizations bent on much smaller aims, such as the personal power of one individual or group of individuals. (And as the players will eventually find out, one or more of these may be fronts for the Calaseans or their servant minions.)