MIDSOUTHCON!
One of the finest small to midsize cons you'll find. There's a little bit of everything in the mix, and an incredibly dedicated batch of volunteers that out it all together.
Gaming, art, costuming, literature, approachable guests, children's programing, two movie rooms - one devoted to anime, science, board games, dealers (of course), a charity read-a-thon, blood drive, costume contest, local writing awards, and a hospitality suite with beer and high caffine drinks included in the price. All the worst problems this con has had in the past few years have (IMH and informed O) stemmed directly from the hotel itself (don't get me started; I just wrote and decided to delete a rant on this). Steve Jackson and Jolly Blackburn have been featured guests in recent years and claim to have had an absolutly wonderful time.
Plus the proceeds go to charity.
I'm a pretty big fan of MidSouthcon.