Are you looking for new systems to try or are you looking for different settings?
If its the former, try HERO. HERO is my favorite system of all: super flexible and once you make your PC, you almost never reference the book again. Mutants & Masterminds is similarly flexible.
If it's the latter, there are many innovative settings out there that you could either run as a game or use as source material in a system you prefer. You've already taken a look at Shadowrun, but others are worthy of examining: RIFTS, Deadlands, Space:1889, Earthdawn, Paranoia and Call of Cthulhu are all very rich with ideas & flavor.
If its the former, try HERO. HERO is my favorite system of all: super flexible and once you make your PC, you almost never reference the book again. Mutants & Masterminds is similarly flexible.
If it's the latter, there are many innovative settings out there that you could either run as a game or use as source material in a system you prefer. You've already taken a look at Shadowrun, but others are worthy of examining: RIFTS, Deadlands, Space:1889, Earthdawn, Paranoia and Call of Cthulhu are all very rich with ideas & flavor.