Nothing lasts forever. However, we've proven to be very adaptable because of extensive tool use and the ability to develop and reproduce much more complex and effective tools than other species. There are only a handful of regions we haven't been able to colonize thoroughly, and many we have are very different from East Africa. When we go, it will have to be a variety of factors, simply because most of these are either not thorough enough to kill everyone or are so far off that it's not likely humanity will even be recognizable. Whatever caused the Permian Mass Extinction could do it, and a large enough impact event would, but drastic, rapid climate change seems more likely right now.