I've certainly played in an odd game here and there. The comedy campaign with my pajama-clad pillow-fighting monk was certainly weird by typical D&D standards, but fun all the same.
That said, I believe a lot of people, particularly adolescents and adults who still act like them, did an awful job handling it when gender-changing cursed items dropped in a campaign. Which is hardly a surprise, given how badly adolescent and puerile adult gamers have handled such basic things as female PCs and even treating female players with basic dignity and/or respect.
It wouldn't be much of a surprise to me if the person who accused me of being "on the rag" for making a rules judgement against them in my capacity as DM was the same kind of person who would call a male player "gay" for playing a female PC, or who would try to tell a male player whose character was gender swapped that his character should cry and have wild mood swings because bewbs and lady-parts. And all of those are things I have actually seen at the gaming table, just not from the same person.
There is no shortage of people in this hobby who behave quite badly (and by quite badly let me clarify that most of it is general a-holishness, but it does get quite extreme as well: I almost left the hobby because of the humiliation and fear I felt when a group I joined through my local hobby shop pushed me to rp the rape of my captured character). Fortunately, some people who do misbehave grow up and regret the idiocy of their hormone-fueled youth. But. some of them never grow up and continue to treat other people as caricatures and stereotypes, or as things to torture for their own amusement.