Sorry, but I can only say that I find it ridiculous to assume that my ability to create a campaign will be hampered by 4E. In fact, I already have a long-running campaign idea and I do not see a point where it could be hindered by daily powers or healing surges.
Maybe I am just thinking totally different from you, but I really absolutely honestly don't get how you can come to this conclusion. You can talk about hand-waving and internal balance or the combat grid all you want, it doesn't seem to get me closer to understanding how the hell this gets in the way of creating a campaign.
Here's my scenario:
Point of Lights is the base assumption. But, even the small points of lights are being threatened. Various groups try to amass power, one (yet not clearly defined, though I an envisioning an undead army) in particular. But as the heroes become aware of the first signs of evil threatening the Points of Lights, they begin to travel the world to create new alliances between the points of lights to eventually create something that can stand up against the looming threats.
Pretty simple, actually. Could be Lord of the Rings, I must admit, but with less focus on magical rings that need to be dropped into Volcanoes.
Where does 4E inhibit this campaign idea?