So, "Region" is a unique rule to enhance the flavor of the Realms in 3e, but it's 4e brother-by-another-mother "Background" doesn't count. And a multi-class only class (which exists in no other setting so far) doesn't count either or an entirely new class doesn't count? The same Dragonmarks and Artificer class available in both editions of the game means that 3e has unique rules for the setting, but 4e doesn't?
To be fair, 'Region' determined your optional starting equipment and which FR Regional/Racial feats you could take. 'Background', AFAIK, is only a static bonus to one of the skills -- or your initiative, which is "the" choice for most optimizers I know.