This thing is starting to look good. There are still some issues that I hope they resolve over the next few months:
1. The marketplace is currently the weakest part of the builder. It looks like they are going to overhaul it next month, and boy does it need it.
2. The ability to house rule.
3. Choice of portrait (uploaded) and the option for the original builder character sheet.
4. There are still some options located in non-intuitive places. Paragon path and epic destiny, for example, should appear in the class tab, not nestled near the bottom of the character details page.
5. The builder still has the annoying habit of selecting things for you (automatically selecting heroic effort instead of the bonus human at-will, automatically selecting lay on hands for paladins, automatically selecting the paragon path for essentials characters).
6. While it has gotten considerably better over time, the builder is still laggy/slow about acknowledging choices. You have to wait for about a half second, for example, for it to register that you increased an ability score while assigning points to to a new character, and sometimes a couple of seconds to register a feat choice. This slows down character creation noticeably compared with the old off-line builder. It is a minor issue but one that I hope they can continue to combat.