Since I started running at upper Heroic, I've sort of hand-waved the setting as the current Realms. I haven't pulled the party into in-depth world development, but rather just take them from point to point in their adventures. As a result the world exposition, that they receive, is generally limited to the interaction that they have with political figures, and the movers & shakers of the world. It could essentially be anywhere.
They're currently in Revenge of the Giants, so they're doing some plane hopping.