I LOVE Fallout New Vegas, so yeah the Ranger Sequoia is awesome
As is "Lucky", the "Mysterious Magnum" (a gun that plays a tune when you draw it cannot be beat lol), my fave though is A Light In Shining Darkness the custom Colt .45 Commander Joshua Graham has, mods that let you use a silencer with that and oh yeah!
Also, the game has the Blade Runner pistol

Lever action 20 guage is one of my faves as well
Glaive from Krull, hell yes!

Adore that film and still awesome weapon
"SNAGA the Sender", Druss the Axeman's axe, mmm....
In SKyrim, fellow made VERY cool mod adding custom designs to the Skyforge weapons, and the Ebony dagger version is gorgeous!
Real life, Puma Bowie Knife, not one of the crazy outlandish things, high quality, small awesome tool.
De Lisle Carbine, sneakiest damn gun ever invented, lol

British totally silent carbine designed to take out Axis sentries etc during WW2.
Read a scifi novel where, because of suicidal spree killers, the cops carried specially adapted guns, like ultra rapid firing .22s but this is the future, and they bullets are loaded with advanced explosive tips...talk about gibbage!
Lawgiver, oh another classic

ever since way back early when 2000AD started Dredd used Ricochet bullets to take out several guys in a lift....oh hell yeah!
BFG 9000 is of course, iconic, but real men did it all with the shotgun
Gladius, most efficient killing weapon ever designed.
and hey, one of my own designs

Drow cutlass!
