The HERO system seems very simulationist from what I've read.
To be more-than-slightly pedantic, Champions/HERO System does a lousy job of simulating comic book reality. Marvel Heroic Roleplay does a great job of it, working on different types of beats and panels and such. Masks: A New Generation isn't too bad at it either, more emergent from the types of scenes where you mark and unmark conditions, but some of the principles for running it directly tie into framing it like a comic book.It definitely simulates comic book reality better than any system I'm aware of. Not so much actual reality. For that, I'm going to go with HarnMaster Gold (HarnMaster 3e has some issues in this regard that keep me from nominating it).

(Dungeons & Dragons)
Rulebook featuring "high magic" options, including a host of new spells.