Its a longshot but Marvel is a possibility. Between the movie franchise and their just launched universe update it would be huge.
There are a bunch of other comics that would also work. Especially if they signed on with a publishing house that gave them a wide range of settings.
Borderlands...
You could also do the classic items that eat/imprison souls. Depending on how "evil" you make these items it introduces some interesting shades of moral gray. The possibilities for paladins of vengeance alone...
Interested
I'm in the area and I am interested. I haven't played DnD since 3.5 but have been looking for an excuse to get the 5e products. I've plaid a bunch of random systems over the years and I'm fairly laid back. Let me know if you would like any more details.