It seems depend largely upon how gritty you want to go and how badass you want the PCs to be.
Berserk (besides the magic system) would work pretty well in D&D, just giving nearly all non-PCs the weak NPC classes, but Darkest Dungeon's vibe should be something with much higher attrition and...
I'll just hop in and say that it's not a cultural issue. It's a legal one.
The US is one of the only countries in the world which doesn't have a loser pays system. In virtually every other country, if you sue someone and lose, you have to pay their legal fees they spent defending themselves...
I think that's largely due to the cost/risk involved.
Coming out with a new TTRPG, novel, or comic book costs a few thousand dollars.
Coming out with even a AA video game or movie costs millions.
Therefore movies & video games don't want to take major risks when other media can. Hence their...