Found an in depth and insightful comparison of V20 versus V5 and their relative playability, a good read: Mechanics and Character Creation in Vampire: the Masquerade (V5)
Blailton makes some fair points in that v5 does nerf vampires considerably in mechanics especially as your percentage chances of passing routine checks and higher are much reduced. Couple that with the Hunger dice mechanics and it is problematic with smaller dice pools being very weak indeed. It...