Mmmm, i would say it doesn't affect it. Remember the chance to destroy is the chance for the Astro effect to take place while the quantum effect multiplies the effect when it takes place. this is why quantum multiplies damage most of the time so in this case it would multiple the effect of Astro...
i dont think so even the normal dnd allows for greater deities up to divine rank 20
Intermediate Deity 12 10,000,000-99,999,999 Horus
Greater Deity 16 100,000,000-999,999,999 Dagda
Elder One 24 1,000,000,000-9,999,999,999 Surtur
My personal take is that it wouldnt affect the inhabitants unless the time lord specifically wants to.
Think of the time lord like a person and the inhabitants of each universe as baterial. When you wake up in the morning move around and stuff, the level or amount of bateria isnt specifically...