I would posit rather than, is it worth learning and adapting to this new book as opposed to using one of the many other books to which you've already adapted?
Nice to know the prevailing opinion is that the best possible stewards of D&D are Hasbro/WotC. What a wonderful world we live in where that's the best we can do.
I don't know...Daggerheart and any version of official D&D (including WotC's current offering) are quite different games. I don't think you can fairly say they have the "same exact" audience.
All of those are excellent choices. SWN would I think be particularly compelling. But I think I would like to run it in Level Up's Voidrunner's Codex rules. Hits all the bases from what I can tell.
Every game you are playing (not every game system) has a setting in which the activities of the PCs take place. that's what is inseparable from the game to my mind.
Well, I hope you get what you want, in your own games. I'm pretty happy with what I'm doing now, but if I see something someone's doing that I want to incorporate into my play, I'll let you know. It's happened before, so you never know.