Holmes might be tricky in 4e but I had no trouble doing him in my home brew with my low magic mods. Watson was a bit harder though.
You can see the original post in my blog 5 Stone Games
or here
Holmes
L10 Half Elf Rogue
S 16
I 18
W 14
D 16
C 16
CH 14
Feats
1 Educated (All Knowledge...