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Curse of the Perceptive Insult: a low, hissing voice whispers the most hurtful, insightful insult possible at each new person met, whilst the cursed is nearby and the victim is not looking at them. You might learn something, but at what cost?
Curse of Fungoid Pallor: your skin is a sickly grey, and disturbingly-shaped, poisonous fungus grows overnight about wherever you sleep.
Curse of Stabbing Knives: at the most crucial and inconvenient moments, you feel just as though someone ran a stilleto into you; all the normal consequences: exclaimations, doubling up, extreme pain, the dread of uncertainty.
Curse of the Mind Mists: all memories come and go; from hour to hour you may forget your name, your companions, your skills, your goal.
Curse of Vermin: diseased insects and other vermin are strangely attracted to you; a creeping swarm will follow behind - and crawl about you when you stop to rest.
Curse of the Whispering Demons: a thousand lesser fiends spread throughout the realm, sitting on shoulders in taverns, and injecting foul untruths about the cursed into every conversation. You will be reviled mightily and in a hundred different ways for years.
Curse of the Thief's Hand: your left hand is ever restless; if you do not keep it under lock and key, it will steal all it can and place the loot into your pack and pockets.
Reason
Principia Infecta