There are some reasons, but not many. The biggest is probably Exotic Weapon Master's Flurry of Strikes, which can only be used with a double weapon or spiked chain. Another is if you are a Revenant Blade (ECS) with a Valenar Double Scimitar. Also, if you were TWFing with a Shalalieghed and Spiked quarterstaff, you'd be hard pressed to find a weapon/spike combo that can out damage those spells.
But other than that, no. Both get 1.5x Str when you don't get to make a full attack (since you are only attacking with one end), but the normal 2hander probably has better features, a higher base damage size, and probably doesn't require EWP to use.
Then again, most damage doesn't come from the weapons base, but rather from other sources of bonus damage, so in the long run, the gap will be pretty small.