I've done both - and run both!
The Intercon's on the East coast of the US - in Boston and New Jersey - are a great place to be exposed to all of the options and varieties of games, styles, and rules.
Intercon C - in March, in Chelmsford Mass, is the next one. I don't have a handy link, but try a google search for it, it will pop up.
The Intercon's are weekend long conventions. There tend to be 5 game slots over the weekend - with some games taking up two slots. Friday night, Sat morning, afternoon and night, and Sunday morning. Occasionally you'll see a midnight game tucked in somewhere. Most games tend to be theater style - with Pre-gen characters and their own rules.
You generally get about 4 or 5 games for each slot, with about 20-30 players needed for each game. Sometimes more, sometimes less. Intercon C, the next one, apparently has tons of pre-registered guests, and long list of games. You generally have a few White Wolf games, using one of their published systems, a few Rules to live by games - as the author is a regular con attendee, and a whole lot of home-brew rules light systems.
The one I wrote and ran was called 'The Unexpected Storm' - 27 odd travelers end up in a strange Inn during a freak snow storm. Plot and character interactions and chaos ensue. It ran, um, a year and a half ago at Intercon A - and was fairly well received, I think.

It was mechanics light, I do need to work on the combat system, try and make it easier and faster, but the plot and characters worked well I think.
Partly because of Intercon, and several healthy LARPing groups in the Boston area, there is lots of cross-over between tabletop and live action gaming. I, at least, haven't seen much animosity. Expect perhaps towards certain *poorly run/written* games - but that can only be expected.