I think that right now there is a glut of D&D book products out. I am hard pressed to think of anything other than a poster map pack adventure (I miss you Fantastic Locations), or a new monster book that would get me interested in purchasing something.
My hope (ok, I don't hope for layoffs but):
1. Staff is reduced or redirected to managing digital efforts (Make Dungeon and Dragon great again)
2. Better, more tightly integrated digital tools like CB, MB and VTT all sharing a common database... that you can use OFFLINE!
3. Serious efforts given to development of next generation RPG. Take lessons learned from 4E/Essentials, as well as competitors. For the love of money and peace in the universe, a less restrictive license.
The only books I was sort of thinking of picking up have already been cancelled, so I probably am a terrible predictor of what WoTC is going to do. It doesn't matter too much to me anyhow, I have my books, I have my offline CB still, and I already cancelled my DDI subscription thanks to a lack of any serious content on the magazines. I really enjoy the 4E game mechanic, but dislike the choices the stewards of the brand are making at the moment.